Premedication with antihistamines and corticosteroids is recommended in patients with a history of mild to moderate reactions to intravenous contrast agents. In particular, the evaluation of soft tissue infections, including cellulitus, myositis, fasciitis, abscess, and septic arthritis are often best evaluated by MRI or CT due to their excellent anatomic resolution and soft tissue contrast. In later stages, nonenhancement of the fascia may be seen due to necrosis, which can be helpful to differentiate from nonnecrotizing fasciitis.3, 28,29, Although more apparent on CT, gas in the soft tissues is represented by punctate or curvilinear T1 and T2 low signal with corresponding blooming artifact on gradient echo sequences.1, 18,25,30 Although a highly specific finding, the absence of soft-tissue gas does not exclude the diagnosis of necrotizing fasciitis.3, 11. In a patient with colon cancer undergoing a workup for metastases, axial CT without contrast (A) shows prominence of the right hilar region (arrow). 2001;176(5):1155-9. CT head without IV contrast Usually Not Appropriate . The need for enhancement with intravenous (IV) contrast depends on the specific clinical indication (Table 1). When does chest CT require contrast enhancement? Given that metformin is excreted through the kidneys, IV contrast may impair metformin clearance from the body putting the patient at risk for metabolic acidosis. CT pulmonary angiography with intravenous contrast in a patient being evaluated for arteriovenous malformation. and transmitted securely. CT is helpful in guiding surgical debridement and drainage by evaluating the extent of soft tissue and osseous involvement, identifying the potential infectious source and identifying potential complications including vascular rupture or tissue necrosis.1, 2,13,22 MAGNETIC RESONANCE IMAGING Federal government websites often end in .gov or .mil. Scout film (a) and contrast-enhanced CT (b) shows intramuscular pockets of gas (arrows) in the left lateral thigh. This can be filled at Baystate Pharmacies at 759 Chestnut Street and 3300 Main Street as well as at many local pharmacies. N Engl J Med. Although it is a clinical diagnosis, imaging is a powerful adjunct to facilitate early diagnosis in equivocal cases. Computed tomography (CT) plays an important role in the diagnosis and treatment of many clinical conditions1 involving the chest wall, mediastinum, pleura, pulmonary arteries, and lung parenchyma. Risk factors include chronic kidney disease, diabetes mellitus, heart failure, older age, anemia, left ventricular systolic dysfunction, and contrast volume. Abdominal and/or pelvic pain-acute or chronic 2. Schmid M, Kossmann T, Duewell S. Differentiation of Necrotizing Fasciitis and Cellulitis Using MR Imaging. Insights Imaging. Axial non-contrast. However, if contrast must be administered within two months of iodine 131 treatment, consultation with an endocrinologist should be considered.7 Administration of iodinated contrast may provoke thyrotoxicosis, although this is rare.12, Approximately 90% of absorbed metformin is excreted by the kidneys within 24 hours. This site needs JavaScript to work properly. References. Alaia E, Chhabra A, Simpfendorfer C et al. % Wall DB, Klein SR, Black S, de Virgilio C. A simple model to help distinguish necrotizing fasciitis from nonnecrotizing soft tissue infection. Diffuse thickening of the superficial fascia, which can be seen in the early phase of necrotizing fasciitis (c). CT LUMBAR SPINE W CONTRAST (IMG214) 72126 72129 72132 EXTREMITIES Fracture, Abnormal pathology. However, patients with a documented anaphylactic reaction to any medication are at higher risk of a reaction to iodinated contrast.9,10, Many centers screen outpatients with suspected renal insufficiency by measuring serum creatinine one month before administration of contrast agents. A ct urogram uses IV contrast (dye) to better evaluate the renal pelvis and ureter (the "tube" connecting your kidneys t. Read More. Family physicians often must determine the most appropriate diagnostic tests to order for their patients. Data Sources: We used the term radiologic contrast to search the following: PubMed Clinical Queries (systematic reviews); the OVID database (all evidence-based medicine reviews; Cochrane Database of Systematic Reviews, ACP Journal Club, Database of Abstracts of Reviews of Effects, Cochrane Central Trial Registry, Cochrane Methodology Register, Health Technology Assessment, and NHS Economic Effectiveness Database); Dynamed; and the U.S. Preventive Services Task Force and Agency for Healthcare Research and Quality clinical guidelines and evidence reports. 2021;50(12):2319-47. During the injection you may feel flushed and get a metallic taste in your mouth. Cellulitis. The American College of Radiology Appropriateness Criteria is a useful online resource. Magn Reson Imaging Clin N Am. Miller TT, Randolph DA, Staron RB, Feldman F, Cushin S. Fat-suppressed MRI of musculoskeletal infection: fast T2-weighted techniques versus gadolinium-enhanced T1-weighted images, Necrotizing fasciitis: unreliable MRI findings in the preoperative diagnosis, Differentiation of necrotizing fasciitis and cellulitis using MR imaging. The most common contrast agents used with CT imaging are barium- and iodine-based. One study showed similar increases in serum creatinine levels between inpatient populations who received IV iodinated contrast and those who did not.16, Noncontrast-enhanced CT is used in patients with head trauma and acute stroke. During the injection you may feel flushed and get a metallic taste in your mouth. This absorption and scattering in turn results in higher CT attenuation values, or enhancement on CT images. Clinical presentations include skin erythema without a well-defined border, increased skin temperature, swelling of the affected area, and regional lymphadenopathy and lymphangitis. Hayeri MR, Ziai P, Shehata ML, Teytelboym OM, Huang BK. Patients with history of anaphylactic reaction should not receive contrast. Laryngeal edema (severe or rapidly progressing), Methylprednisolone (Medrol), 32 mg orally 12 and 2 hours before contrast administration; plus diphenhydramine (Benadryl), 50 mg intravenously, intramuscularly, or orally 1 hour before contrast administration, Prednisone, 50 mg orally 13, 7, and 1 hour before contrast administration; plus diphenhydramine, 50 mg intravenously, intramuscularly, or orally 1 hour before contrast administration, Normal renal function and no comorbid disorder, Metformin (Glucophage) can be continued when contrast is administered; serum creatinine does not need to be measured, Normal renal function and at least one comorbid disorder, Metformin should be discontinued when contrast is administered; if the patient remains clinically stable and has no new intercurrent risk factors for renal impairment, metformin may be resumed in 48 hours without repeating serum creatinine measurement, Metformin should be discontinued when contrast is administered; resume only after careful reevaluation and monitoring of renal status, Noncontrast-enhanced CT of the head is the preferred initial study if performed within three hours of acute symptom onset; contrast-enhanced CT should be obtained for patients with symptoms lasting longer than three hours; contrast-enhanced CT combined with CT angiography of the neck may be needed for follow-up, Thin section high-resolution CT without contrast, Extremity soft tissue swelling, infection, or trauma, Contrast is necessary if vascular involvement or injury is suspected, Scan suspected area of trauma in cervical, thoracic, or lumbar spine, Abdominal and pelvic CT; oral or rectal contrast agent based on institutional preference, Protocols vary depending on cancer type and stage, Diverticulitis; suspected complications of inflammatory bowel disease, Intravenous contrast agent for diverticulitis; oral and/or rectal contrast agent can be administered to visualize bowel, Noncontrast-enhanced CT is sensitive for calcifications (chronic pancreatitis); contrast-enhanced CT is best for evolving pancreatitis or pancreatic pseudocyst, Many centers now include venous phase CT of the pelvis and lower extremities in combination with CT angiography of the lung. Prior to contrast administration, patients should be asked about previous allergy to CT contrast.
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