milk thistle depression

And Selenium too. One reported effect of milk thistle is that it can boost breast milk production in lactating mothers. We encourage you to discuss any decisions about treatment or care with your health care provider. Overall, more high-quality research is needed to define the doses and clinical effects of this fascinating herb. One human trial found it to work as well as fluoxetine to manage OCD symptoms. Antidepressant and Anti-anxiety Effects of Milk Thistle Silibinin is one of the main flavonoids produced by milk thistle, which is reported to inhibit the inflammatory response by suppressing the nuclear factor-kappa B (NF-B) pathway. Milk thistle. To ensure quality and potency in your herbal remedies, why not grow your own? To provide you with the most relevant and helpful information, and understand which Abstract Allergic asthma is a chronic inflammatory disease regulated by coordination of T-helper2 (Th2) type cytokines and inflammatory signal molecules. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. Luckily, more and more experts are turning to natural remedies to answer that question and circumvent the litany of side effects. Well go over the methods that doctors use to determine this and provide a chart, Blessed thistle is an herb with a long history of use for digestive issues and breastfeeding. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. Our website services, content, and products are for informational purposes only. Using different formulations together increases the risk of an overdose. One study questioned the benefits of milk thistle for liver diseases. Its anti-inflammatory and antioxidant properties mean that it is possibly neuroprotective and could help prevent the decline in brain function you experience as you age (14, 15). 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167, Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. privacy practices. Did you know that milk thistle has recently been touted as a natural remedy to help manage the debilitating symptoms of OCD? While milk thistle has been traditionally used in pregnant and breastfeeding women, its safety is unknown. Summary Milk thistle may help lower blood sugar levels in people with type 2 diabetes, though more high-quality studies are needed. Milk thistle has been used in alternative medicine as a possibly effective aid in treating heartburn, or seasonal allergy symptoms. Reflux Risk and Relief View More . One particular area of interest is in milk thistle's ability to protect and perhaps restore the liver. U.S. Department of Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of Health and Human Services. Summary The active ingredients in milk thistle have been shown in animals to improve the effects of some cancer treatments. Do not use extra milk thistle to make up the missed dose. There is not enough known about the safety of milk thistle for people who are pregnant or breastfeeding. Adv Ther. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. If you have breast cancer, uterine cancer, ovarian cancer, endometriosis or uterine fibroids, consider avoiding milk thistle. Therefore, it may be best to avoid milk thistle during these life stages. 2016;68(4):1026-1073. doi:10.1124/pr.115.010843. Effects of Silybum marianum (L.) Gaertn. In one such study, a 45-day course of silymarin, the active component of milk thistle, increased antioxidant capacity and reduced generalized inflammation in adults with type 2 diabetes compared with a placebo. The data is very limited, but one randomized controlled study found that mothers taking 420 mg of silymarin for 63 days produced 64% more milk than those taking a placebo (37). If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. Milk thistle is effective at naturally reversing toxicity in the body, including the harmful . Milk Thistle: Health Benefits, Safety Information, Dosage, and More - WebMD Taken in appropriate doses, oral use of milk thistle appears to be safe. It's also proven useful in treating skin that's been damaged by radiation during breast cancer treatment. Song X, Zhou B, Cui L, Lei D, Zhang P, Yao G, Xia M, Hayashi T, Hattori S, Ushiki-Kaku Y, Tashiro SI, Onodera S, Ikejima T. Neurochem Res. J Diabetes Res. When reported, side effects for milk thistle are generally gut disturbances like diarrhea, nausea or bloating. Interactions. They are seen in very high numbers in the brains of people with Alzheimers disease, meaning that milk thistle could potentially be used to help treat this difficult condition (21). Natural Medicines. However, there is no solid evidence that supports these claims. eCollection 2022. a history of endometriosis or uterine fibroids. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. In fact, in studies where high doses were used for long periods, only about 1% of people experienced side effects (1). Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). And, most recently, milk thistle is gaining traction as a natural remedy to help manage the symptoms of OCD. The benefits of milk thistle remain unclear for this purpose and the limited research on milk thistle and breast milk has been done primarily in animals. Summary One study has shown that people taking milk thistle supplements experienced a decrease in the number of acne lesions on their body. Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, The 10 Best Herbs for Liver Health: Benefits and Precautions, How to Get Rid of Acne: 14 Home Remedies for Pimples. Together, you can make shared, well-informed decisions. This herb (also known as Silybum marianum) is native to the Mediterranean region. You may opt-out of email communications at any time by clicking on It's typically recommended to avoid taking multiple supplements for the same cause at the same time. Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have: an allergy to plants such as ragweed, chrysanthemums, marigolds, or daisies. This prickly plant has distinctive purple flowers and white veins, which traditional stories say were caused by a drop of the Virgin Marys milk falling onto its leaves. If you choose to use milk thistle, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Milk thistle might also help prevent insulin resistance and slow the growth of cancer,. I have bad anxiety, mild depression and obsessive thoughts - Reddit Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in people with type 2 diabetes. According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. Subjects were assessed with the National Institute of Mental Health Trichotillomania Severity Scale (primary outcome), the Massachusetts General Hospital Hair Pulling Scale, Clinical Global Impression scale, and measures of depression, anxiety, and psychosocial . 1982;17:51721. Milk thistle is often sold as an herbal supplement. Dosing of milk thistle ranged from 150 mg twice a day to 300 mg twice a day. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements. If youre pregnant or breastfeeding, check with your doctor before using milk thistle. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. In 2010, a double-blind, placebo-controlled study compared the effects of milk thistle to the antidepressant Prozac (fluoxetine) in treating OCD (600 milligrams of milk thistle vs 30 milligrams of Prozac daily). The benefits of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Ask your doctor for advice. Researchers believe that silymarin reduced the oxidative stress traditionally attributed with diabetes (7). In test-tube and animal studies, silymarin has been shown to prevent oxidative damage to brain cells, which could help prevent mental decline (16, 17). Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, Know the Science: How Medications and Supplements Can Interact, Know the Science: How To Make Sense of a Scientific Journal Article, How To Find Information About Complementary Health Approaches on PubMed, Dietary Supplements: What You Need To Know. Bookshelf 2014;2014:941085. doi:10.1155/2014/941085. Phytother Res. 2022 Nov 29;23(23):14968. doi: 10.3390/ijms232314968. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. One study also found that it may slightly extend the life expectancy of people with cirrhosis of the liver due to alcoholic liver disease (10). Some supplements are close to chemicals in efficacy like saffron (standardized extract) for depression and magnolia bark extract for anxiety. Find out more on the side effects of statins.

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